Not sure how best to explain this. I've set a bind for Prevent Window Detection so that when I go in game, I can continue to use my second monitor without tabbing.

I've found that if I have mIRC or Spotify already open when I go in game them use this bind it will cause both programs to act like they aren't there. The only way to fix seems to be closing them from the taskbar and restarting. Once they've restarted, it's fine and will only occur if I use my bind again.

For ref, the bind I have is Alt + Ctrl + L

I don't use the Multi-Monitor taskbars